Changing the way Pernicious Anaemia is diagnosed and treated

Pernicious Anaemia

What is Pernicious Anaemia and what does it do?

Pernicious Anaemia treatment during COVID

Guidelines, Articles & Resources

The Chair's Blog

Martyn Hooper’s experiences as chair of the Society

Healthcare Professionals

Information to help you and your patients

Latest News

Long COVID and Pernicious Anaemia

Long COVID and Pernicious Anaemia

Last Updated: 21 February 2021: You may remember that last month we wrote to the Chief Medical Officers in the UK to point out that the symptoms of Long-Covid were remarkably similar to those of Vitamin B12 Deficiency and that..

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Did you know ?


Of patients waited 5 years or more for diagnosis


Of patients were initially misdiagnosed


Of patients are unhappy with their treatment

Get Involved

Member Support Groups

PAS Volunteer

Come and join us, and other other members of the society to share your experience of living with Pernicious Anaemia in a supportive and friendly environment.


Top 10 PA priorities

Pernicious Anaemia Priority Setting Partnership

The results are in!
We have the Top 10 Research Priorities for Pernicious Anaemia!


PAS Volunteer

Help out! Let us know what you can or want to do to help the PAS and all our members

Become a Member of the Pernicious Anaemia Society

With your help we can continue to do our valuable work, supporting those that need it and campaigning to secure future improvements in detection and treatment of this illness. The more members we have the bigger our voice will be in getting the way in which Pernicious Anaemia is diagnosed and treated thoroughly reviewed. Join us and help us bring about this much needed review. Your membership fee or donations go towards the running of society, but also help us to fund research projects, awareness campaigns and many other activities.


If you have been recently diagnosed with Pernicious Anaemia, or if you suspect that you might have Pernicious Anaemia you will probably have lots of questions that you would like answers to.
What's the difference between B12 Deficiency and Pernicious Anaemia ?
Vitamin B12 deficiency can be dietary-related (vegans and strict vegetarians) or non-dietary related for which there are several causes. Pernicious Anaemia is the most common cause of a vitamin B12 deficiency.
Pernicious Anaemia is caused by either the patient not producing Intrinsic Factor that is needed to bind with vitamin B12 from food before it enters the blood stream or the Intrinsic Factor is being produced but is then destroyed by antibodies to the Intrinsic Factor – auto-immune Pernicious Anaemia. Because the patient is either not producing Intrinsic Factor or is destroying the Intrinsic Factor that has been produced the B12 cannot be absorbed from food.
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How is Pernicious Anemia diagnosed ?
The test used to diagnose Pernicious Anaemia is the anti-intrinsic factor antibody test (IFAB).
If the test is positive, then it is 95% certain that the patient will have Pernicious Anaemia. However, it will identify only 50% – 70% of patients with the antibodies. So, if you test positive for the antibody you will almost certainly have Pernicious Anaemia. But is it is negative it does NOT rule our Pernicious Anaemia.
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How is Pernicious Anaemia treated ?
Vitamin B12 injections are still the preferred method of treating Pernicious Anaemia. There are many other types of treatments available including sub-lingual sprays, drops and lozenges along with skin patches and nasal sprays but the efficacy and cost–effectiveness of oral treatment in wider population-based settings has yet to be established.
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What are the symptoms of Pernicious Anaemia ?
Common symptoms include extreme fatigue, weakness, shortness of breath, brain fog, tingling, numbness, beefy tongue, depression, irritability, mood swings, burning feet, dizzyness, loss of appetite, problems concentrating.

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Our Mission

To secure a full and comprehensive review of the way in which Pernicious Anaemia is diagnosed and treated that will lead to more timely diagnoses and better treatment

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